Chicago is unbeaten in each of its last four series openers, and is 7-0 in its last seven home games against a left-handed starting pitcher.
Score prediction: Cubs 6, Cardinals 4
💰 Cardinals vs. Cubs prediction & best bet
Over 7.5 (-125)
Clay Holmes looked rusty in his Cubs debut after making his first start in nearly three months. Last Saturday, Holmes was tagged for four runs in four innings, and a season-low one of his 12 outs came via strikeout. Meanwhile, the Cardinals just beat two of the best pitchers in the game (Cristopher Sanchez and Zack Wheeler) on consecutive days while scoring nine runs and going 6-for-16 with runners in scoring position.
Conversely, Matthew Liberatore has a career 5.29 ERA in road starts, in line with his 5.30 ERA and 1.446 WHIP at Wrigley Field.
